Ole Gunnar Solskjaer has already guided his squad to 10 wins and a draw since taking over from Jose Mourinho, who was sacked in December, but the Tuesday night game is arguably his biggest test so far.
French champions are without Neymar, right back Thomas Meunier and star striker Edinson Cavani for the game at Old Trafford but Solskjaer will still be wary of the threat the French side pose and will pick his team accordingly.
Solskjaer made six changes for the game against Fulham and it’s likely that he will make more changes for this game with Victor Lindelof and Marcus Rashford both available again.
Matteo Darmian and Antonio Valencia are the only absentees.
Chris Smalling impressed verus Fulham and could be pushing Phil Jones for a starting role alongside Victor Lindelof – also rested at the weekend – though Tuesday’s match should see Jones and Lindelof resume their budding partnership.
As for PSG, Thomas Tuchel will be without star man Neymar, with the Brazil forward out of both legs of the tie due to a metatarsal injury.
Edinson Cavani was forced off with a thigh injury against Bordeaux the Saturday before the first leg and is also out along with Thomas Meunier, who is on the sidelines due to concussion.
Kylian Mbappe, who was rested ahead of Tuesday’s trip to Old Trafford, came onto replace the Uruguay international and will almost certainly lead the line for PSG.
Man Utd vs PSG predicted line-ups
Man Utd XI (4-3-3): De Gea; Young, Lindelof, Jones, Shaw; Matic, Herrera, Pogba; Lingard, Rashford, Martial
PSG XI (4-2-3-1): Buffon; Kehrer, Kimpembe, Silva, Bernat; Marquinhos, Verratti; Alves, Draxler, Di Maria; Mbappe